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prank-msa.info | ||
prank-msa.SlackBuild | ||
README | ||
slack-desc |
PRANK: Probabilistic Alignment Kit PRANK is a probabilistic multiple alignment program for DNA, codon and amino-acid sequences. It is based on a novel algorithm that treats insertions correctly and avoids over-estimation of the number of deletion events. In addition, PRANK borrows ideas from maximum likelihood (ML) methods used in phylogenetics and correctly takes into account the evolutionary distances between sequences. Lastly, PRANK allows for defining a potential structure for sequences to be aligned and then, simultaneously with the alignment, predicts the locations of structural units in the sequences. NOTE! The dependencies listed in the REQUIRED field are not needed for building PRANK. They are, however, highly recommended for the complete functionality of the program: 1) Progressive alignment requires a guide tree. If no tree is provided, PRANK constructs one by calling MAFFT to make a quick alignment and infers an NJ tree from the evolutionary distances based on that. 2) The standard PRANK algorithm is based on an exhaustive search of the best pairwise solution. PRANK uses Exonerate to anchor the pairwise alignments and thus speed up the process. 3) To improve the ancestral reconstruction, PRANK uses BppAncestor from the BppSuite. NOTE 2: This will not build on a 32bit system.