diff --git a/academic/ugene/slack-desc b/academic/ugene/slack-desc
index 895ea0e0fa..eaaddfa2e8 100644
--- a/academic/ugene/slack-desc
+++ b/academic/ugene/slack-desc
@@ -15,5 +15,5 @@ ugene: UGENE integrates widely used bioinformatics tools within a common
 ugene: user nterface. The toolkit supports multiple biological data formats
 ugene: and allows the retrieval of data from remote data sources.
 ugene:
-ugene: Home: http://ugene.unipro.ru/
-ugene: References: /usr/doc/ugene-1.16.2/References
+ugene: Home: http://ugene.net/
+ugene: References: /usr/doc/ugene-1.21.0/References
diff --git a/academic/ugene/ugene.SlackBuild b/academic/ugene/ugene.SlackBuild
index 63adecdde7..3d8a8bce86 100644
--- a/academic/ugene/ugene.SlackBuild
+++ b/academic/ugene/ugene.SlackBuild
@@ -23,7 +23,7 @@
 #  ADVISED OF THE POSSIBILITY OF SUCH DAMAGE.
 
 PRGNAM=ugene
-VERSION=${VERSION:-1.16.2}
+VERSION=${VERSION:-1.21.0}
 BUILD=${BUILD:-1}
 TAG=${TAG:-_SBo}
 
@@ -51,7 +51,7 @@ elif [ "$ARCH" = "i686" ]; then
 elif [ "$ARCH" = "x86_64" ]; then
   SLKCFLAGS="-O2 -fPIC"
   LIBDIRSUFFIX="64"
-  QMAKECONFIG="CONFIG+=64"
+  QMAKECONFIG="CONFIG+=x64"
 else
   SLKCFLAGS="-O2"
   LIBDIRSUFFIX=""
@@ -77,7 +77,7 @@ find -L . \
 sed -i "s:/lib:/lib${LIBDIRSUFFIX}:g" src/ugene_globals.pri
 sed -i "s:/share/man:/man:g" src/ugene_globals.pri
 
-qmake $QMAKECONFIG -r \
+qmake-qt5 $QMAKECONFIG -r \
 QMAKE_CFLAGS="$SLKCFLAGS" \
 QMAKE_CXXFLAGS="$SLKCFLAGS"
 make
diff --git a/academic/ugene/ugene.info b/academic/ugene/ugene.info
index 1bd33c04cd..1bde13608d 100644
--- a/academic/ugene/ugene.info
+++ b/academic/ugene/ugene.info
@@ -1,10 +1,10 @@
 PRGNAM="ugene"
-VERSION="1.16.2"
-HOMEPAGE="http://ugene.unipro.ru/"
-DOWNLOAD="https://sourceforge.net/projects/sboppetrov/files/ugene/ugene-1.16.2.tar.gz"
-MD5SUM="b55a6f7194d6dd89469d9f2f4b92d8f1"
+VERSION="1.21.0"
+HOMEPAGE="http://ugene.net/"
+DOWNLOAD="http://sourceforge.net/projects/sboppetrov/files/ugene/ugene-1.21.0.tar.gz"
+MD5SUM="d9745720a28e448b3c92bf7d03d510db"
 DOWNLOAD_x86_64=""
 MD5SUM_x86_64=""
-REQUIRES=""
+REQUIRES="qt5"
 MAINTAINER="Petar Petrov"
 EMAIL="slackalaxy@gmail.com"