diff --git a/academic/pysam/pysam.SlackBuild b/academic/pysam/pysam.SlackBuild
index 2e69a15150..b4a536bcb2 100644
--- a/academic/pysam/pysam.SlackBuild
+++ b/academic/pysam/pysam.SlackBuild
@@ -2,7 +2,7 @@
 
 # Slackware build script for pysam
 
-# Copyright 2017-2022 Rob van Nues
+# Copyright 2017-2023 Rob van Nues
 # All rights reserved.
 #
 # Redistribution and use of this script, with or without modification, is
@@ -25,7 +25,7 @@
 cd $(dirname $0) ; CWD=$(pwd)
 
 PRGNAM=pysam
-VERSION=${VERSION:-0.20.0}
+VERSION=${VERSION:-0.21.0}
 BUILD=${BUILD:-1}
 TAG=${TAG:-_SBo}
 PKGTYPE=${PKGTYPE:-tgz}
@@ -80,7 +80,7 @@ find -L . \
  \( -perm 666 -o -perm 664 -o -perm 640 -o -perm 600 -o -perm 444 \
   -o -perm 440 -o -perm 400 \) -exec chmod 644 {} \;
 
-# pysam now at htslib-1.16; SBo-htslib is at 1.16:
+# pysam now at htslib-1.17; SBo-htslib is at 1.17:
 # can use system htslib:
 export HTSLIB_LIBRARY_DIR=/usr/lib$LIBDIRSUFFIX
 export HTSLIB_INCLUDE_DIR=/usr/include
diff --git a/academic/pysam/pysam.info b/academic/pysam/pysam.info
index 75735bb31a..37d066c020 100644
--- a/academic/pysam/pysam.info
+++ b/academic/pysam/pysam.info
@@ -1,8 +1,8 @@
 PRGNAM="pysam"
-VERSION="0.20.0"
+VERSION="0.21.0"
 HOMEPAGE="https://github.com/pysam-developers/pysam"
-DOWNLOAD="https://pypi.python.org/packages/source/p/pysam/pysam-0.20.0.tar.gz"
-MD5SUM="765653d9a606fb992670803d2633becb"
+DOWNLOAD="https://pypi.python.org/packages/source/p/pysam/pysam-0.21.0.tar.gz"
+MD5SUM="dca7fb36d2cf69ef887fe05ddd726998"
 DOWNLOAD_x86_64=""
 MD5SUM_x86_64=""
 REQUIRES="htslib"